Article

Spliceosome Inhibition in <i>SF3B1</i>-Mutated Uveal Melanoma

2022-09-23

Abstract excerpt

Treatment of uveal melanoma (UM) patients with metastatic disease is unfortunately limited. Twenty percent of UM harbor a mutation in splicing factor gene SF3B1 , suggesting that aberrant spliceosome functioning plays a vital role in tumorigenesis. Splicing inhibitors exploit the preferential sensitivity of spliceosome compromised leukemic cells to these compounds. We have studied the effect of splicing inhibitor...

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Literature Corpus work: 8436ac1a-7ec2-5424-8a69-0d597071701c
DOI: 10.1101/2022.09.20.22280164

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