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Article

[Screening of drugs that selectively inhibit uveal melanoma cells with SF3B1 mutations].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University - 20 Dec 2021

Luo X, Ren C, Liu X, Zhang G, Huang S, Yu L, Li Y

Abstract excerpt

OBJECTIVE: To screen compounds that can selectively inhibit uveal melanoma cells with splicing factor 3B subunit 1 (SF3B1) mutations in comparison with isogenic SF3B1 wild-type counterparts in a cell model of SF3B1 mutant allele knockout. METHODS: Principal component analysis was used to analyze transcriptome alternative splicing in TCGA cohorts of uveal melanoma with wild-type SF3B1 and SF3B1 mutations, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35012916
DOI: 10.12122/j.issn.1673-4254.2021.12.12
PMCID: PMC8752436

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