Article
The Impact of Spliceosome Inhibition in SF3B1-Mutated Uveal Melanoma.
Investigative ophthalmology & visual science - 1 Oct 2024
Nguyen Josephine Q N, Drabarek Wojtek, Leeflang Aïsha M C H J, Brands Tom, van den Bosch Thierry P P, Verdijk Robert M, van de Werken Harmen J G, van Riet Job, Paridaens Dion, de Klein Annelies, Brosens Erwin, Kiliç Emine
Abstract excerpt
Purpose: Unfortunately, treatment of patients with uveal melanoma (UM) with metastatic disease is limited. Twenty percent of patients with UM harbor a mutation in the splicing factor gene SF3B1, suggesting that aberrant spliceosome function plays a vital role in tumorigenesis. Splicing inhibitors exploit the preferential sensitivity of spliceosome-compromised leukemic cells to these compounds. Methods: We studied...
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