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Key residue Unlocks Dual PIP <sub>2</sub> -Dependent and Independent Gating in G Protein-Gated Inwardly Rectifying Potassium Channels

2025-02-18

Abstract excerpt

G protein-gated inwardly rectifying potassium (GIRK) channels mediate membrane hyperpolarization in response to G protein-coupled receptor activation and are critical for regulating neuronal excitability. The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP 2 ) is essential for regulating a large family of ion channels, and disruptions in PIP 2 interactions contribute to some neurological disease...

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Literature Corpus work
5eb8b765-6d31-591b-809c-ebfd7a7ea604
DOI
10.1101/2025.02.14.637896
Open publication

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Key residue Unlocks Dual PIP <sub>2</sub> -Dependent and Independent Gating in G Protein-Gated Inwardly Rectifying Potassium ChannelsDOI 10.1101/2025.02.14.637896
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