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Article

Design of therapeutic proteins with enhanced stability.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2009

Chennamsetty Naresh, Voynov Vladimir, Kayser Veysel, Helk Bernhard, Trout Bernhardt L

Abstract excerpt

Therapeutic proteins such as antibodies constitute the most rapidly growing class of pharmaceuticals for use in diverse clinical settings including cancer, chronic inflammatory diseases, kidney transplantation, cardiovascular medicine, and infectious diseases. Unfortunately, they tend to aggregate when stored under the concentrated conditions required in their usage. Aggregation leads to a decrease in antibody...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19571001
DOI: 10.1073/pnas.0904191106
PMCID: PMC2715526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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