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Article

Prediction of Aggregation Prone Regions of Therapeutic Proteins

22 Apr 2010

Abstract excerpt

Therapeutic proteins such as antibodies are playing an increasingly prominent role in the treatment of numerous diseases including cancer and rheumatoid arthritis. However, these proteins tend to degrade due to aggregation during manufacture and storage. Aggregation decreases protein activity and raises concerns about an immunological response. We have recently developed a method based on full antibody atomistic...

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Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 20411962
DOI: 10.1021/jp911706q

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