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Article

Probing the stability-limiting regions of an antibody single-chain variable fragment: a molecular dynamics simulation study

5 Jul 2011

Abstract excerpt

Antibody single-chain variable fragments (scFvs) offer particular advantages over the full-size antibodies, including easy expression, efficient local concentration and fast body clearance. However, scFvs typically show low thermal stability that limits their biomedical and biotechnological applications. In this study, we examined the thermal stability of the human and murine vascular endothelial growth factor...

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Share to Glycosylation and Glycoproteins Research
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PMID: 21729946
DOI: 10.1093/protein/gzr029

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