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Article

Conformational stability as a design target to control protein aggregation.

Protein engineering, design & selection : PEDS - 1 May 2014

Costanzo Joseph A, O'Brien Christopher J, Tiller Kathryn, Tamargo Erin, Robinson Anne Skaja, Roberts Christopher J, Fernandez Erik J

Abstract excerpt

Non-native protein aggregation is a prevalent problem occurring in many biotechnological manufacturing processes and can compromise the biological activity of the target molecule or induce an undesired immune response. Additionally, some non-native aggregation mechanisms lead to amyloid fibril formation, which can be associated with debilitating diseases. For natively folded proteins, partial or complete...

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Identifiers

PMID: 24722670
DOI: 10.1093/protein/gzu008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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