Article
Advanced analyses of kinetic stabilities of iggs modified by mutations and glycosylation.
Protein science : a publication of the Protein Society - 1 Jul 2015
Sedlák Erik, Schaefer Jonas V, Marek Jozef, Gimeson Peter, Plückthun Andreas
Abstract excerpt
The stability of Immunoglobulin G (IgG) affects production, storage and usability, especially in the clinic. The complex thermal and isothermal transitions of IgGs, especially their irreversibilities, pose a challenge to the proper determination of parameters describing their thermodynamic and kinetic stability. Here, we present a reliable mathematical model to study the irreversible thermal denaturations of...
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