Article

Nonallosteric Sirtuin Enzyme Activation: Characterization of Hit Compounds

2020-04-18

Abstract excerpt

<h4>ABSTRACT</h4> Mammalian sirtuins (SIRT1-SIRT7) are a family of nicotinamide adenine dinucleotide (NAD + )-dependent protein deacylases that play critical roles in lifespan and age-related diseases. The physiological importance of sirtuins has stimulated intense interest in designing sirtuin-activating compounds. However, except for allosteric activators of SIRT1-catalyzed reactions that are limited to partic...

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Literature Corpus work: 840aea29-298e-5c0b-ba1e-84efeca28844
DOI: 10.1101/2020.04.17.045187

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