Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic potential of activators and inhibitors of sirtuins

1 Sept 2010

Abstract excerpt

Sirtuins are evolutionary conserved NAD(+)-dependent acetyl-lysine deacetylases and ADP ribosyltransferases dual-function enzymes involved in the regulation of metabolism and lifespan. Sirtuins are also implicated in determining the balance between apoptosis, cell survival, and cell proliferation. In humans, seven sirtuins isoforms (SIRT₁₋₇) have been identified that localize either in the nucleus, cytoplasm, or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Calcium signaling and nucleotide metabolism
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20848588
DOI: 10.1002/biof.112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic potential of activators and inhibitors of sirtuinsPMID 20848588Read ↗

Sirtuin activators as an anti-aging intervention for longevitySemantic proximity Read ↗

Sirtuin functions and modulation: from chemistry to the clinicSemantic proximity Read ↗

Sirtuin Modulators: Mechanisms and Potential Clinical ImplicationsSemantic proximity Read ↗

Zebrafish as a Model Organism to Evaluate Drugs Potentially Able to Modulate Sirtuin ExpressionSemantic proximity Read ↗

Sirtuins, a promising target in slowing down the ageing processSemantic proximity Read ↗

Sirtuin Modulators in Cellular and Animal Models of Human DiseasesSemantic proximity Read ↗

Sirtuins and their Biological Relevance in Aging and Age-Related DiseasesSemantic proximity Read ↗

Sirtuins, Aging, and MedicineSemantic proximity Read ↗

The Sirtuin family: therapeutic targets to treat diseases of agingSemantic proximity Read ↗

Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug TargetsSemantic proximity Read ↗

Biological and Potential Therapeutic Roles of Sirtuin DeacetylasesSemantic proximity Read ↗

Sirtuins, a key regulator of ageing and age-related neurodegenerative diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.