Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated SIRT7

Abstract excerpt

The sirtuins are NAD + -dependent lysine deacylases, comprising seven isoforms (SIRT1–7) in humans, which are involved in the regulation of a plethora of biology, including gene expression and metabolism. The sirtuins share a common hydrolytic mechanism but display preferences for different ε -N -acyllysine substrates. SIRT7 deacetylates targets in nuclei and nucleoli but remains one of the lesser studied of the...

Topics

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• Enzyme Activation
• Gene Knockdown Techniques
• Histones
• RNA, Ribosomal
• RNA, Ribosomal, 5.8S
• RNA, Ribosomal, 5S
• RNA, Transfer
• Sirtuins

Identifiers and source

Literature Corpus work

18a18ae8-ed78-5cff-bfd2-a8752666c138

DOI

10.1101/2023.06.16.545261