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Article

Mechanism of activation for the sirtuin 6 protein deacylase.

The Journal of biological chemistry - 31 Jan 2020

Klein Mark A, Liu Can, Kuznetsov Vyacheslav I, Feltenberger John B, Tang Weiping, Denu John M

Abstract excerpt

The histone deacetylase sirtuin 6 (SIRT6) regulates numerous biological functions, including transcriptional repression, DNA repair, and telomere maintenance. Recombinant SIRT6 displays catalytic efficiencies 2 orders of magnitude greater for long-chain deacylation than deacetylation against peptide substrates; however, deacetylation can be enhanced by allosteric small-molecule activators. Here, we investigated...

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Identifiers

PMID: 31822559
DOI: 10.1074/jbc.RA119.011285
PMCID: PMC6996886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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