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Article

Molecular modeling study for conformational changes of Sirtuin 2 due to substrate and inhibitor binding.

Journal of biomolecular structure & dynamics - 1 Jan 2012

Sakkiah Sugunadevi, Chandrasekaran Meganathan, Lee Yuno, Kim Songmi, Lee Keun Woo

Abstract excerpt

Sirtuin is a member of NAD(+)-dependent deacetylase family. The structural details of Sirtuin 2 (SIRT2) complex will be very useful to discover the drug which might have beneficial effects on various diseases like cancer, diabetes, etc. Unfortunately, SIRT2 complex structure is not available yet,...

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Source

Identifiers

PMID: 22694102
DOI: 10.1080/07391102.2012.680026

Genes

SIRT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22694102-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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