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Identification of small molecular inhibitors of SIRT3 by computational and biochemical approaches a potential target of breast cancer

30 May 2024

Abstract excerpt

-dependent lysine deacylase, involved in the regulation of various cellular activities. Dysregulation of SIRT3 activity has been linked to several types of cancer, including breast cancer. Because of its ability to stimulate adaptive metabolic pathways, it can aid in the survival and proliferation of breast cancer cells. Finding new chemical compounds targeted towards SIRT3 was the primary goal of the current...

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PMID: 38816444
DOI: 10.1038/s41598-024-63177-7

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