Integrative computational simulations and functional assays decode allosteric dysregulation in a pathogenic SIRT6 variant.

Abstract excerpt

SIRT6, a critical member of the NAD+-dependent deacetylase family, plays a central role in regulating key biological processes such as DNA repair, transcriptional regulation, aging, and tumor suppression. Although multiple SIRT6 mutations have been identified across cancer types, the structural mechanisms underlying their functional impact remain largely unclear. In this study, we demonstrate that L197P, a point...

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