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Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

1 May 2008

Abstract excerpt

We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6. Via a yeast genetic screen, biochemical assays, and target validation studies in mammalian cells, we show that tenovins act through inhibition of the...

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Identifiers

PMID: 18455128
DOI: 10.1016/j.ccr.2008.03.004

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