Article

Sex-specific blood-brain barrier alterations and vascular biomarkers underlie chronic stress responses in mice and human depression

2021-04-24

Abstract excerpt

Prevalence, symptoms, and treatment of depression all point toward major sex differences. Social stress-induced neurovascular pathology is associated with depressive symptoms in male mice however it remains unknown if it contributes to this sexual dimorphism. Here, we report that chronic social and subchronic variable stress promoted sex-specific blood-brain barrier (BBB) molecular and morphological alterations in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83fbbcb6-c7fe-53e5-8407-0d051ddf79f1
DOI: 10.1101/2021.04.23.441142

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sex-specific blood-brain barrier alterations and vascular biomarkers underlie chronic stress responses in mice and human depressionDOI 10.1101/2021.04.23.441142Read

Pericytes modulate brain vascular integrity in social stress and depressionSemantic proximity Read

Stress-induced dysfunction of neurovascular astrocytes contributes to sex-specific behavioral deficitsSemantic proximity Read

Stress-induced dysfunction of neurovascular astrocytes in the prefrontal cortex contributes to sex-dependent deficits in cognition and behaviorSemantic proximity Read

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice.Semantic proximity Read

Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuseSemantic proximity Read

Sex Differences in Stress Susceptibility as a Key Mechanism Underlying Depression RiskSemantic proximity Read

Amplified Microglial Dysfunction and Brain Lesions in Mouse Models for Comorbidity of Chronic Stress and Intracerebral HypoperfusionSemantic proximity Read

Anxiety and Depression in Women’s Cardiovascular Health: Risk Modifiers, Mechanisms and Clinical ImplicationsSemantic proximity Read

Chronic stress exposure alters the gut barrier: sex-specific effects on microbiota and jejunum tight junctionsSemantic proximity Read

New Evidence for the Role of the Blood-Brain Barrier and Inflammation in Stress-Associated Depression: A Gene-Environment Analysis Covering 19,296 Genes in 109,360 Humans.Semantic proximity Read

The psychodynamic psychotherapist's guide to the interaction among sex, genes, and environmental adversity in the etiology of depression for women.Semantic proximity Read

Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depressionSemantic proximity Read