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The NLRP3 inflammasome selectively drives IL-1β secretion by <i>Pseudomonas aeruginosa</i> infected neutrophils and regulates bacterial killing <i>in vivo</i>

2022-04-07

Abstract excerpt

<h4>ABSTRACT</h4> Macrophages infected with Gram-negative bacteria expressing Type III secretion system (T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-mediated IL-1β secretion and pyroptosis. Here we examined inflammasome signaling in neutrophils infected with Pseudomonas aeruginosa strain PAO1 that expresses the T3SS effectors ExoS and ExoT. IL-1β secretion by neutrophils required the...

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Literature Corpus work
83f98871-7aa9-5dea-b2e8-19d61f220104
DOI
10.1101/2022.04.07.487503
Open publication

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The NLRP3 inflammasome selectively drives IL-1β secretion by <i>Pseudomonas aeruginosa</i> infected neutrophils and regulates bacterial killing <i>in vivo</i>DOI 10.1101/2022.04.07.487503
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