Article
The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection.
PloS one - 1 Jan 2012
Galle Marlies, Jin Shouguang, Bogaert Pieter, Haegman Mira, Vandenabeele Peter, Beyaert Rudi
Abstract excerpt
The type III secretion system (T3SS) is a complex nanomachine of many pathogenic gram-negative bacteria. It forms a proteinaceous channel that is inserted into the host eukaryotic cell membrane for injection of bacterial proteins that manipulate host cell signaling. However, few studies have focused on the effector-independent functions of the T3SS. Using a murine model of acute lung infection with Pseudomonas...
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