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The <i>Achromobacter</i> Type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes

2023-04-06

Abstract excerpt

Achromobacter species are newly recognized opportunistic, pro-inflammatory Gram-negative pathogens in immunocompromised individuals, but how they interact with the innate immune system to drive inflammation is poorly understood. We created sctV (Type 3 Secretion System baseplate) mutants in three Achromobacter clinical isolates from two species and showed that all three required the T3SS to induce cell death in...

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Identifiers and source

Literature Corpus work
db934eb1-65be-5e78-a71b-d8505d6d8e80
DOI
10.1101/2023.04.06.535904
Open publication

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