Epithelial Atg5 Deficiency Intensifies Caspase‐11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS–STING–NLRP3 Axis in Macrophages During Pseudomonas Infection

Abstract excerpt

Abstract Pseudomonas aeruginosa (P. aeruginosa) infections pose a significant threat to public health, underscoring the need for deeper insights into host cellular defenses. This study explores the critical role of autophagy‐related protein 5 (ATG5) in lung epithelial cells during P. aeruginosa infection. Single‐cell RNA transcriptomics revealed a pronounced enrichment of autophagy pathways in type II alveolar...