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A VgrG2b fragment cleaved by caspase-11/4 promotes <i>Pseudomonas aeruginosa</i> infection through suppressing the NLRP3 inflammasome

2024-07-04

Abstract excerpt

The T6SS of Pseudomonas aeruginosa plays an essential role in the establishment of chronic infections. Inflammatory cytokines mediated by inflammasomes are crucial for the body to resist bacterial infections. Here we found that during the infection of P. aeruginosa , non-canonical inflammasome was activated in macrophages, but the activation of downstream NLRP3 inflammasome was inhibited. The VgrG2b of P. aerug...

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Identifiers and source

Literature Corpus work
590bad76-f57b-5fb5-8288-d39355ff0363
DOI
10.1101/2024.07.02.601667
Open publication

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