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Article

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption

15 Jul 2023

Abstract excerpt

Human airway and corneal epithelial cells, which are critically altered during chronic infections mediated by Pseudomonas aeruginosa, specifically express the inflammasome sensor NLRP1. Here, together with a companion study, we report that the NLRP1 inflammasome detects exotoxin A (EXOA), a ribotoxin released by P. aeruginosa type 2 secretion system (T2SS), during chronic infection. Mechanistically, EXOA-driven...

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PMID: 37642996
DOI: 10.1084/jem.20230104

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