Article

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in <i>C. elegans</i>

2021-08-12

Abstract excerpt

<h4>ABSTRACT</h4> One of the most robust and reproducible methods to prolong lifespan in a variety of organisms is inhibition of the mTORC1 (mechanistic target of rapamycin complex 1) pathway. mTORC1 is a metabolic sensor that promotes anabolic growth when nutrients are abundant. Inhibition of mTORC1 extends lifespan, but also frequently has other effects such as stunted growth, slowed development, reduced fertil...

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Literature Corpus work: 83f6ae10-05b5-5314-a06e-8254ad6d3a73
DOI: 10.1101/2021.08.12.456148

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