Article

Glycosylphosphatidylinositol biosynthesis restricts coronavirus infection via the regulation of LY6E

2025-02-10

Abstract excerpt

<h4>ABSTRACT</h4> Coronaviruses, including SARS-CoV-2, rely on host factors for their replication and pathogenesis, while hosts deploy defense mechanisms to counteract viral infections. Although numerous host proviral factors have been identified, the landscape of host restriction factors and their underlying mechanisms remain less explored. Here, we conducted genome-wide CRISPR knockout screens using three disti...

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Literature Corpus work: 83f5c48b-90f2-5aa5-9c30-e1dc800fdd73
DOI: 10.1101/2025.02.08.637211

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