Article

VPS29 exerts opposing effects on endocytic viral entry

2021-08-08

Abstract excerpt

<h4>SUMMARY</h4> Emerging zoonotic viral pathogens threaten global health and there is an urgent need to discover host and viral determinants influencing infection. We performed a loss-of-function genome-wide CRISPR screen in a human lung cell line using HCoV-OC43, a human betacoronavirus. One candidate gene, VPS29, was required for infection by HCoV-OC43, SARS-CoV-2, other endemic and pandemic threat coronavirus...

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Literature Corpus work: 14d29e9e-c9db-5d4c-9cd0-ee8a3a761e14
DOI: 10.1101/2021.08.06.455441

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