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Membrane protein CRISPR screen identifies RPSA as an essential host factor for porcine epidemic diarrhea virus replication

30 Jul 2025

Abstract excerpt

Porcine epidemic diarrhea, caused by porcine epidemic diarrhea virus (PEDV), is one of the most devastating diseases in the global pig industry due to its high mortality rate in piglets. The host factors required for PEDV replication, including receptors, remain poorly understood. Here, we developed a porcine membrane-protein-scale CRISPR/Cas9 knockout (PigMpCKO) library and performed two rounds of PEDV...

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PMID: 40736249
DOI: 10.1128/jvi.00649-25

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