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OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism

20 Mar 2019

Abstract excerpt

A human cytomegalovirus (HCMV) pentameric glycoprotein complex (PC), gH-gL-UL128-UL130-UL131A, is necessary for viral infection of clinically relevant cell types, including epithelial cells, which are important for interhost transmission and disease. We performed genome-wide CRISPR/Cas9 screens of different cell types in parallel to identify host genes specifically required for HCMV infection of epithelial cells....

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PMID: 30894498
DOI: 10.1073/pnas.1814850116

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