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Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infections

6 Aug 2025

Abstract excerpt

Porcine epidemic diarrhea virus (PEDV) is a globally distributed alphacoronavirus with economic importance that can cause severe watery diarrhea and even death in piglets. To identify host factors essential for PEDV infection, we performed a genome-wide CRISPR/Cas9 screen in human hepatocellular carcinoma cells (Huh7) using the highly virulent PEDV GIIb strain GDU. Several genes involved in the sialic acid and...

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PMID: 40767522
DOI: 10.1128/mbio.01628-25

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