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Article

YIPF5 is an essential host factor for porcine epidemic diarrhea virus double-membrane vesicle formation

27 May 2025

Abstract excerpt

Porcine epidemic diarrhea virus (PEDV) is a major coronavirus in swine, causing substantial economic losses in the industry. To deepen our understanding of the PEDV-host cell interactions, we performed whole-genome CRISPR/Cas9 screens on porcine IPEC-J2 and IPI-2I cell lines to identify key host factors essential for PEDV infection. Our study identified the Yip family 5 (YIPF5) protein as a critical host factor,...

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PMID: 40422075
DOI: 10.1128/jvi.00320-25

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