Back to search

Article

Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience

2025-01-10

Abstract excerpt

The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain controversial. While rodent studies have highlighted active roles for adult-born immature neurons in the hippocampus under both healthy conditions and in Alzheimer’s disease (AD), evidence from the human brain is limited and lacks detailed molecular characteriza...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d550fd97-b143-5f0f-8a88-6107c80a46eb
DOI
10.1101/2025.01.08.631686
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilienceDOI 10.1101/2025.01.08.631686
A roadmap to human hippocampal neurogenesis in adulthood, aging and AD.Semantic proximity
Molecular Diversity Among Adult Human Hippocampal and Entorhinal CellsSemantic proximity
Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer’s diseaseSemantic proximity
Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humansSemantic proximity
A Scalable Human Brain Cell Atlas Foundation Model Dissects the Cellular Immune Codes and Cognitive ResilienceSemantic proximity
Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer’s diseaseSemantic proximity
Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humansSemantic proximity
Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory intratelencephalic cortical neuronsSemantic proximity
A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolutionSemantic proximity
A single-cell transcriptome atlas of cell diversity in human prefrontal cortex across the postnatal lifespanSemantic proximity
Identifying gene expression profiles associated with neurogenesis and inflammation in the human subependymal zone from development through agingSemantic proximity
Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammationSemantic proximity
Select a neighboring publication to make it the new centre.