Electroacupuncture Promotes Synaptic Recovery After Cerebral Ischemia-Reperfusion by Activating SIRT1 to Inhibit the NF-κB Pathway and Regulate Astrocyte Phenotypic Transformation.

Abstract excerpt

Functional recovery after cerebral ischemia-reperfusion injury (CIRI) depends on synaptic plasticity, which is profoundly modulated by astrocyte phenotypes-the neurotoxic A1 phenotype exacerbates damage, while the A2 phenotype supports repair. Electroacupuncture (EA) is neuroprotective, yet whether it promotes synaptic repair by orchestrating this phenotypic switch remains elusive. We hypothesized that EA drives...

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