Taohong Siwu Decoction switches the detrimental/reparative phenotypes of astrocytes via RhoA/ROCK2/Profilin-1 axis to bolster oligodendrogenesis and remyelination after ischemic stroke.

Abstract excerpt

ETHNOPHARMACOLOGICAL RELEVANCE: Promoting remyelination is crucial for recovery after ischemic stroke and astrocyte polarization toward detrimental A1 or reparative A2 phenotypes shapes the post-stroke microenvironment. Taohong Siwu Decoction (THSWD) has neuroprotective effects, but its impact on remyelination and astrocyte polarization remains unclear. RhoA/ROCK2/Profilin-1 (PFN1) signals may be key regulators....

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