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Article

Matrine treatment induced an A2 astrocyte phenotype and protected the blood-brain barrier in CNS autoimmunity.

Journal of chemical neuroanatomy - 1 Nov 2021

Jing Yilei, Ma Rui, Chu Yaojuan, Dou Mengmeng, Wang Mengru, Li Xinyu, Zhu Lin

Abstract excerpt

Type 1 astrocytes (A1), which are highly proinflammatory and neurotoxic, are prevalent in multiple sclerosis (MS). In addition, in MS and its animal model, experimental autoimmune encephalomyelitis (EAE), immune cells must cross the blood-brain barrier (BBB) and infiltrate into the parenchyma of the central nervous system (CNS) in order to induce neurological deficits. We have previously reported that treatment...

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Identifiers

PMID: 34280490
DOI: 10.1016/j.jchemneu.2021.102004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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