Article

Aggressive Cholesterol Lowering Normalizes Atherosclerosis Regression in <i> Jak2 <sup>V617F</sup> </i> Mice

2025-07-27

Abstract excerpt

<h4>Background</h4> The Jak2 V617F ( Jak2 VF ) mutation is an important cause of both clonal hematopoiesis of indeterminate potential (CHIP) and myeloproliferative neoplasms (MPN). Mouse models of Jak2 VF CHIP and MPN show accelerated atherosclerosis progression, driven by macrophage inflammasome activation. We undertook the present study to assess the hypothesis that ongoing inflammation would impede ather...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83cd09ee-fe50-5d6d-9950-1dbac5252f15
DOI: 10.1101/2025.07.23.666334

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aggressive Cholesterol Lowering Normalizes Atherosclerosis Regression in <i> Jak2 <sup>V617F</sup> </i> MiceDOI 10.1101/2025.07.23.666334Read

Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2V617F mice.Semantic proximity Read

Clonal hematopoiesis JAKs up plaque formation.Semantic proximity Read

JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.Semantic proximity Read

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesisSemantic proximity Read

Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity.Semantic proximity Read

CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate ImmunitySemantic proximity Read

Link between aging and atheroprotection in <i>Mif</i> -deficient atherosclerotic miceSemantic proximity Read

Pro-atherogenic diet accelerates tumor growth in mice through IL-1β and myeloid cell-derived VEGF-ASemantic proximity Read

Targeting TPO/MPL Signaling to Mitigate JAK2V617F-driven Cardiac Microvascular DiseaseSemantic proximity Read

Ppm1d Clonal Hematopoiesis Does Not Promote Atherosclerosis in Murine Models.Semantic proximity Read

B Cell–Activating Factor Neutralization Aggravates AtherosclerosisSemantic proximity Read

IL-1β promotes MPN disease initiation by favoring early clonal expansion of <i>JAK2</i> -mutant hematopoietic stem cellsSemantic proximity Read