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Article

Aggressive cholesterol lowering normalizes atherosclerosis regression in Jak2V617F mice.

Journal of lipid research - 1 Mar 2026

Hardaway Brian D, Fidler Trevor P, Tavallaie Mojdeh, Hsu Cheng-Chieh, Schiavone Sandra, Xiao Tong, Wang Ranran, Wang Nan, Tall Alan R

Abstract excerpt

The Jak2V617F (Jak2VF) mutation is an important cause of both clonal hematopoiesis of indeterminate potential (CHIP) and myeloproliferative neoplasms (MPNs). Mouse models of Jak2VF CHIP and MPN show accelerated atherosclerosis progression, driven by macrophage inflammasome activation. We undertook the present study to assess the hypothesis that ongoing inflammation would impede atherosclerosis resolution in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41720401
DOI: 10.1016/j.jlr.2026.101003
PMCID: PMC13014939

Genes

AIM2
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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