JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.

doi:10.1038/s41467-022-34469-1

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Article

JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.

Nature communications - 3 Nov 2022

Al-Rifai Rida, Vandestienne Marie, Lavillegrand Jean-Rémi, Mirault Tristan, Cornebise Julie, Poisson Johanne, Laurans Ludivine, Esposito Bruno, James Chloé, Mansier Olivier, Hirsch Pierre, Favale Fabrizia, Braik Rayan, Knosp Camille, Vilar Jose, Rizzo Giuseppe, Zernecke Alma, Saliba Antoine-Emmanuel, Tedgui Alain, Lacroix Maxime, Arrive Lionel, Mallat Ziad, Taleb Soraya, Diedisheim Marc, Cochain Clément, Rautou Pierre-Emmanuel, Ait-Oufella Hafid

Abstract excerpt

JAK2V617F mutation is associated with an increased risk for athero-thrombotic cardiovascular disease, but its role in aortic disease development and complications remains unknown. In a cohort of patients with myeloproliferative neoplasm, JAK2V617F mutation was identified as an independent risk factor for dilation of both the ascending and descending thoracic aorta. Using single-cell RNA-seq, complementary...

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Identifiers

PMID: 36329047
DOI: 10.1038/s41467-022-34469-1
PMCID: PMC9633755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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