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Identification of Genes Regulating Breast Cancer Dormancy in 3D Bone Endosteal Niche Cultures

16 Jan 2019

Abstract excerpt

Abstract Tumor cell dormancy is a significant clinical problem in breast cancer. We used a three-dimensional (3D) in vitro model of the endosteal bone niche (EN), consisting of endothelial, bone marrow stromal cells, and fetal osteoblasts in a 3D collagen matrix (GELFOAM), to identify genes required for dormancy. Human triple-negative MDA-MB-231 breast cancer cells, but not the bone-tropic metastatic variant,...

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PMID: 30651373
DOI: 10.1158/1541-7786.mcr-18-0956

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