Article
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway.
Nature cell biology - 1 Jan 2014
Mohseni Morvarid, Sun Jianlong, Lau Allison, Curtis Stephen, Goldsmith Jeffrey, Fox Victor L, Wei Chongjuan, Frazier Marsha, Samson Owen, Wong Kwok-Kin, Wong Kwok-Kim, Kim Carla, Camargo Fernando D
Abstract excerpt
The Hippo-YAP pathway is an emerging signalling cascade involved in the regulation of stem cell activity and organ size. To identify components of this pathway, we performed an RNAi-based kinome screen in human cells. Our screen identified several kinases not previously associated with Hippo signalling that control multiple cellular processes. One of the hits, LKB1, is a common tumour suppressor whose mechanism...
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