Article
Whole genome exon arrays identify differential expression of alternatively spliced, cancer-related genes in lung cancer.
Nucleic acids research - 1 Nov 2008
Xi Liqiang, Feber Andrew, Gupta Vanita, Wu Maoxin, Bergemann Andrew D, Landreneau Rodney J, Litle Virginia R, Pennathur Arjun, Luketich James D, Godfrey Tony E
Abstract excerpt
Alternative processing of pre-mRNA transcripts is a major source of protein diversity in eukaryotes and has been implicated in several disease processes including cancer. In this study we have performed a genome wide analysis of alternative splicing events in lung adenocarcinoma. We found that 2369 of the 17 800 core Refseq genes appear to have alternative transcripts that are differentially expressed in lung...
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