Article

Lactylation-driven FTO-mediated m <sup>6</sup> A modification of CDK2 aggravates diabetic microvascular anomalies

2023-05-19

Abstract excerpt

Diabetic retinopathy (DR) is a leading cause of irreversible vision loss in working-age populations. FTO is an N 6 -methyladenosine (m 6 A) demethylase that participates in various biological events, while its role in DR remains elusive. Herein, we detected elevated FTO expression in retinal proliferative membranes of DR patients. FTO promoted endothelial cell (EC) cell cycle progression and tip cell formation t...

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Literature Corpus work: 838d02ed-fd51-57c3-a3d3-d454525efd2d
DOI: 10.1101/2023.05.19.541470

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