Article

PRMT5 is a therapeutic target in choroidal neovascularization

2022-03-30

Abstract excerpt

Ocular neovascular diseases including neovascular age-related macular degeneration (nvAMD) are widespread causes of blindness. Patients’ non-responsiveness to currently used biologics that target vascular endothelial growth factor (VEGF) poses an unmet need for novel therapies. Here, we identify protein arginine methyltransferase 5 (PRMT5) as a novel therapeutic target for nvAMD. PRMT5 is a well-known epigenetic e...

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Literature Corpus work: 772c31e0-9692-5fb7-9642-2732c2f9e30b
DOI: 10.1101/2022.03.30.486275

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