YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

Abstract excerpt

<title>Abstract</title> <p>Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms remain largely unknown. Here, we report that lactylation in microglia is critical for retinal neovascularization. Using lactylome and proteomic analyses, we identified a list of hyperlactylated proteins in the c...

Topics

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• Autophagy in Disease and Therapy
• Epigenetics and DNA Methylation
• Gestational Diabetes Research and Management
• Immune cells in cancer
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• Systemic Lupus Erythematosus Research

Identifiers and source

Literature Corpus work

7483af2c-12c8-59ea-a8db-9c820af06d72

DOI

10.21203/rs.3.rs-910016/v1