Article

Oral 8-aminoguanine against age-related retinal degeneration

2024-05-06

Abstract excerpt

<title>Abstract</title> <p>Visual decline in the elderly is often attributed to retinal aging, which predisposes the tissue to pathologies such as age-related macular degeneration. Currently, effective oral pharmacological interventions for retinal degeneration are limited. We present a novel oral intervention, 8-aminoguanine (8-AG), targeting age-related retinal degeneration, utilizing the aged Fischer 344 rat m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2a2b8c64-3f9d-5d67-ba07-9ead84fabc58
DOI: 10.21203/rs.3.rs-4022389/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oral 8-aminoguanine against age-related retinal degenerationDOI 10.21203/rs.3.rs-4022389/v1Read

Age-related macular degeneration (AMD): pathogenesis and therapy.Semantic proximity Read

Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal ModelsSemantic proximity Read

Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin TherapySemantic proximity Read

Pathophysiology of Age-Related Macular Degeneration: Implications for TreatmentSemantic proximity Read

Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic TargetSemantic proximity Read

Halofantrine protects photoreceptors in multiple models of retinal degenerationSemantic proximity Read

Rat retinal transcriptome: Effects of aging and AMD-like retinopathySemantic proximity Read

Oxidative stress and its downstream signaling in aging eyesSemantic proximity Read

[Atrophic age-related macular degeneration].Semantic proximity Read

Oxidative stress and epigenetics in ocular vascular aging: an updated reviewSemantic proximity Read

Role of Oxidative Stress in Retinal Disease and the Early Intervention Strategies: A ReviewSemantic proximity Read

Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatmentSemantic proximity Read