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Mesona chinensis Extract Ameliorates Retinal Angiopathy in a Zebrafish Model of Diabetic Retinopathy by Targeting Thymidylate Synthase in Folate Metabolism

2025-11-26

Abstract excerpt

<title>Abstract</title> <p> Retinal neovascularization in diabetic retinopathy (DR) is a major cause of vision loss. Folate-mediated one-carbon metabolism (OCM) is crucial for nucleotide synthesis and cell proliferation. We hypothesized that dysregulated OCM, particularly involving thymidylate synthase (TYMS), contributes to DR pathogenesis. Using a zebrafish DR model and human retinal endothelial cells, we asse...

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Literature Corpus work: 7c8b4ae0-b1cc-5809-a35e-8b86edc033d4
DOI: 10.21203/rs.3.rs-8091004/v1

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