Article

Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy

2024-01-08

Abstract excerpt

<title>Abstract</title> <p>Healthy blood vessels supply neurons to preserve metabolic function. In blinding proliferative retinopathies (PRs), pathological neovascular tufts often emerge in lieu of needed physiological revascularization of the ischemic neuroretina. Here we show that metabolic shifts in the neurovascular niche define angiogenic fate. Fatty acid oxidation (FAO) metabolites accumulated in human and...

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Literature Corpus work: 9e2db9dc-ae28-56fb-a276-abd5ae1353ed
DOI: 10.21203/rs.3.rs-3683532/v1

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