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Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21

6 Jan 2023

Abstract excerpt

Trehalose is the nonreducing disaccharide of glucose, evolutionarily conserved in invertebrates. The living skin equivalent (LSE) is an organotypic coculture containing keratinocytes cultivated on fibroblast-populated dermal substitutes. We demonstrated that human primary fibroblasts treated with highly concentrated trehalose promote significantly extensive spread of the epidermal layer of LSE without any...

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PMID: 36609486
DOI: 10.1038/s42003-022-04408-3

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