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Article

Impact of Lenvatinib on OATP1B Activity in Patients with Hepatocellular Carcinoma

2026-05-12

Abstract excerpt

<b>Aims: </b>Lenvatinib (LEN) inhibits organic anion transporting polypeptide 1B1 (OATP1B1) <i>in vitro</i>, raising concerns about potential risk for transporter-mediated drug–drug interactions (DDIs). This study evaluated the <i>in vivo</i> impact of LEN on OATP1B activity in patients with hepatocellular carcinoma (HCC), using coproporphyrin-I (CP-I) as an endogenous biomarker. <b>Methods:</b> In this prospectiv...

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Literature Corpus work
83866dc7-0c77-53e0-8c04-3bdecbc295de
DOI
10.22541/authorea.15003181/v1
Open publication

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