Article
Influences of ABC transporter and CYP3A4/5 genetic polymorphisms on the pharmacokinetics of lenvatinib in Chinese healthy subjects.
European journal of clinical pharmacology - 1 Aug 2020
Li Jiaming, Wang Xiaoqian, Ning Chen, Wang Zhaoyu, Wang Yao, Zheng Ming, Zhang Siliang, Lu Yang, Zhang Yongjie, Li Ning, Chen Xijing, Zhao Di
Abstract excerpt
PURPOSE: To investigate whether the CYP3A4/5 and ABC transporter genetic polymorphisms could affect the pharmacokinetics of lenvatinib in Chinese healthy subjects. METHODS: Thirty-two healthy Chinese volunteers were enrolled and took oral administration of 8 mg lenvatinib. Plasma concentration of lenvatinib was determined by UPLC-MS/MS, the CYP3A4*1G, CYP3A5*3, ABCB1 (3435 C>T, 1236 C>T, 2677 G>T/A), ABCG2 (421...
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